Approaches to the biomimetic synthesis of β-lactam antibiotics
The C4 benzoyloxy substituted β-lactams (65)-(68) were formed by the copper-promoted reaction of β-lactarns (42)-(45) with t-butyl perbenzoate. The benzoyloxylation of the azetidin-2-one ring occurs at C4 with no competing reaction at the C3 position. The relative ease of abstraction by t-butoxy ra...
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| Language: | en |
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University of Canterbury. Chemistry
2013
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| Online Access: | http://hdl.handle.net/10092/7982 |