Design, synthesis and testing of β-strand mimics as protease inhibitors

Design, synthesis and testing of β-strand mimics as protease inhibitors

Chapter 1 gives background information on proteases and discusses the concept of protease inhibition as a therapeutic strategy for humans. It introduces the key concept that conformation defines biological activity. It also outlines how proteases almost universally bind their substrate/inhibitors in...

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Bibliographic Details
Main Author: Aitken, Steven Geoffrey
Language:en
Published: University of Canterbury. Chemistry 2009
Subjects:
Beta-strand
Peptidomimetics
drug design
calpain inhibitors
protease inhibitors
computational chemistry
molecular modeling
ADME
Cataract
anti-cataract drugs
Beta-strand mimic
SAR
structure activity relationships
RCM
ring closing metathesis
Online Access:http://hdl.handle.net/10092/1984

Internet

http://hdl.handle.net/10092/1984

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