Antigens and cancer pathways targeted by de-N-acetyl polysialic acid monoclonal antibodies
Polysialic acid (PSA) is a developmentally regulated glycan made of repeating sialic acid monomers with α2-8 linkages. PSA has very limited expression in adults, and modifies only a few cell-surface proteins. However, PSA is overexpressed in several human cancers and is associated with metastasis an...
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| Language: | en_US |
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2017
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| Online Access: | https://hdl.handle.net/2144/23840 |