Histological, cellular, and molecular abnormalities in forebrain and spinal cord of three distinct mouse models of Down syndrome
Down syndrome (DS) is a developmental disorder caused by a triplication of human chromosome 21, which contains approximately 550 genes. DS is the most common autosomal aneuploidy occurring with an incidence of 1 in 793 live births. Hallmarks of DS include abnormal central nervous system (CNS) develo...
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| Language: | en_US |
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2017
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| Online Access: | https://hdl.handle.net/2144/23413 |