The effect of sequence and environment on the structure and dimerization of amyloid precursor protein
Aggregation of amyloid β (Aβ) protein has been linked to the development of Alzheimer's Disease (AD). The genesis of Aβ involves the cleavage Amyloid Precursor Protein (APP) by β-secretase, producing the 99-residue C99 peptide, and the subsequent cleavage of C99 by γ-secretase to produce Aβ. A...
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| Language: | en_US |
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2016
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| Online Access: | https://hdl.handle.net/2144/15180 |