Meta-analysis of safety data: approximation of arcsine transformation and application of mixture distribution modeling
Meta-analysis is frequently used in the analysis of safety data. In dealing with rare events, the commonly used risk measures, such as the odds ratio, or risk difference, or their variance, can become undefined when no events are observed in studies. The use of an arcsine transformation and arcsine...
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| Language: | en_US |
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2015
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| Online Access: | https://hdl.handle.net/2144/13134 |