Exploring integrin and growth factor receptor crosstalk mechanisms
The pro-invasive integrin αvβ6 is upregulated in a range of carcinomas, from normally very low levels, and is associated with poor prognosis. Therapeutic targeting of αvβ6 with inhibitory antibodies has produced promising results in breast cancer models in vivo. Preclinical evidence has suggested th...
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University of Liverpool
2018
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.762740 |