C9orf72 frontotemporal dementia and amyotrophic lateral sclerosis : investigating repeat pathology in cell culture models and human post-mortem brain
A GGGGCC repeat expansion in the first intron of chromosome 9 open reading fame 72 (C9orf72) is the most common known genetic cause of both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeats are transcribed into RNA in both sense and antisense orientations, which aggr...
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University College London (University of London)
2016
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.746143 |