Mechanism of cobalt nanoparticle-induced cytotoxicity and inflammation in human macrophages

The underlying mechanism of metal-on-metal (MoM) implants failure is still unclear. Cobalt could be the active agent due to its high toxicity and Co exposure can also occur in the environment and industry. Co(II) mimics hypoxia by stabilizing hypoxia-inducible factor (HIF)-1α, responsible for cellul...

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Bibliographic Details
Main Author: Nyga, Agata Teresa
Other Authors: Tetley, Teresa ; Hart, Alister
Published: Imperial College London 2015
Subjects:
610
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.733031