A genome-scale investigation of clavulanic acid biosynthesis by Streptomyces clavuligerus in batch and chemostat cultures using transcriptomic and fluxomic analysis
Streptomyces clavuligerus produces the potent beta-lactamase inhibitor clavulanic acid, which is used in conjunction with other beta-lactam antibiotics. Although the genome of S. davuligerus has not yet been sequenced, tools were developed to study the metabolic flux distribution (fluxomics) and gen...
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University of Surrey
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.731087 |