Complexity-generating reactions and the synthesis of alkaloids
This thesis describes attempts to apply the furan oxidative N-spirocyclisation methodology to the synthesis of three alkaloids, namely pandamarilactone-1, lycopladine D and hederacine B. Starting from 5-chloro-1-pentyne, pandamarilactone-1 is synthesised in 10 steps and 9% overall yield. The structu...
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University of Oxford
2016
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.728964 |