Tuning the sulfonyl fluoride warhead towards new proteasome inhibitors : alpha-substituted sulfonyl fluorides and vinyl sulfonyl fluorides
Sulfonyl fluorides have recently been described as “privileged warheads” in chemical biology due to the right balance of reactivity and stability that these electrophiles possess. Peptido sulfonyl fluorides (β-PSFs) have shown to be particularly potent as proteasome inhibitors in recent years. Tunin...
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University of Glasgow
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.726718 |