Inhibition of monocarboxylate transporter 1 by AZD3965 as a therapeutic approach in oncology
Many tumours display a metabolic phenotype distinct from non‐malignant cells, with an increased reliance on glycolysis. This results in a greater production of lactate even under aerobic conditions. Lactate efflux is facilitated by monocarboxylate transporters 1‐4 (MCT1‐4) and is essential to mainta...
| Main Author: | |
|---|---|
| Published: |
University of Newcastle upon Tyne
2017
|
| Subjects: | |
| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.722391 |