Computational investigation of the DNA binding domain of p53 : a drive towards novel therapeutics
p53 is a marginally stable protein that is mutated in 50 % of all human cancers. The region of the protein that contains most of these mutations is the DNA binding domain (DBD). This DBD controls the transcription of p53-dependent genes through the binding of DNA, and is the main focus of the work p...
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University of Southampton
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.714584 |