An investigation into the catalytic mechanism of vitamin B6 biosynthesis using X-ray crystallography and UV-Vis spectroscopy
The catalytic mechanism of the Pdx1 subunit of the pyridoxal 5’-phosphate (PLP) syn-thase enzyme complex has been the subject of intense study since its discovery in 1999. Pdx1 uses two active sites (P1 and P2) to perform a complex reaction combining ribose 5-phosphate, ammonia and glyceraldehyde 3-...
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University of Southampton
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.714583 |