Assessment of the influence of chromatin elements on stability of recombinant protein production in amplified CHO cells
Therapeutic proteins require proper folding and post-translational modifications (PTMs) to be effective and biologically active. Chinese hamster ovary (CHO) cells are the most frequently used host for commercial production of therapeutic proteins and DHFR-mediated gene amplification is extensively a...
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University of Manchester
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.713541 |