Engineering cholera toxin for the targeted delivery of oligonucleotides

Half of the 20 best-selling prescription drugs of 2014 were large biologic therapeutics, however to date there have only been two licensed non-aptamer oligonucleotide drugs. Oligonucleotides have proven highly successful at modification of gene expression in the laboratory, but the lack of a robust...

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Bibliographic Details
Main Author: Machin, Darren Christopher
Other Authors: Webb, Michael E. ; Turnbull, W.Bruce ; Macdonald, Andrew ; Andrews, Benjamin I.
Published: University of Leeds 2016
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.707042