Bimodal antagonism of PKA by ARHGAP36
PKA is a ubiquitous kinase whose activity is controlled by the second messenger cAMP downstream of GPCR signalling. PKA is a tetrameric holoenzyme composed of a homodimer of regulatory subunits (PKAR) which each bind and inhibit a catalytic subunit (PKAC). In this conformation the enzyme is inactive...
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University of Liverpool
2016
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.706819 |