Novel approaches to optimize assessment of hepatic uptake clearance in vitro and translation to in vivo
Increased use of complex cellular systems to study hepatic drug disposition in vitro has been associated with increased complexity of models applied for data analysis. Despite these advances, a tendency to under-predict transporter-mediated hepatic clearance using in vitro data is generally reported...
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University of Manchester
2016
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701118 |