Functional and structural analysis of the angucyclinone ketoreductase SimC7
The natural product simocyclinone D8 (SD8) is a potent DNA gyrase inhibitor produced by Streptomyces antibioticus Tü6040. The biosynthetic simocyclinone (sim) gene cluster has been sequenced and a hypothetical biosynthetic pathway has been proposed. The tetraene linker in SD8 was suggested to be the...
| Main Author: | |
|---|---|
| Published: |
University of East Anglia
2016
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.699587 |