A comparative study of phosphoinositide and calcium signalling by G-protein-coupled receptors and growth factor receptors in human SH-SY5Y neuroblastoma cells

This study investigated G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK)-mediated signal transduction via phospholipase C (PLC). A transient elevation of intracellular [Ca2+] ([Ca2+]i) was identified in response to PDGF-BB. Despite the recruitment and phosphorylation of PLC-, the...

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Bibliographic Details
Main Author: Wheldon, Lee Mark
Published: University of Leicester 2001
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696955