Biochemical characterisation of the catalytic domain of neuropathy target esterase

Neuropathy target esterase (NTE) is an integral membrane protein found predominantly in neurones. Covalent modification of NTE's active site serine, by certain organophosphates (OPs), results in a neurodegenerative syndrome. NTE's physiological substrate is unknown and its catalytic activi...

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Bibliographic Details
Main Author: Atkins, Jane
Published: University of Leicester 2000
Subjects:
612
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696759