DNA gyrase : mechanism of supercoiling and interaction with quinolones

DNA gyrase is unique among topoisomerases in its ability to introduce negative supercoils into closed-circular DNA. Deletion of the C-terminal DNA-binding domain of the A subunit of gyrase gives rise to an enzyme that behaves like a conventional type II topoisomerase, suggesting that the unique prop...

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Bibliographic Details
Main Author: Kampranis, Sotirios C.
Published: University of Leicester 1998
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.696423