The design, synthesis and biological evaluation of novel small-molecule HDAC inhibitors
NAD+-Dependent histone deacetylases, also called sirtuins, are a family of enzymes that catalyse the cleavage of acetyl groups from lysine amino acid residues in histones and a variety of nonhistone proteins, playing a critical role in numerous biological processes. They have been found to be deregu...
| Main Author: | |
|---|---|
| Other Authors: | |
| Published: |
Imperial College London
2012
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.692266 |