The design, synthesis and biological evaluation of novel small-molecule HDAC inhibitors

NAD+-Dependent histone deacetylases, also called sirtuins, are a family of enzymes that catalyse the cleavage of acetyl groups from lysine amino acid residues in histones and a variety of nonhistone proteins, playing a critical role in numerous biological processes. They have been found to be deregu...

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Bibliographic Details
Main Author: Di Fruscia, Paolo
Other Authors: Fuchter, Matthew ; Stronach, Euan
Published: Imperial College London 2012
Subjects:
572
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.692266