Directed molecular evolution of novel DNA aptamers raised against an antibiotic resistant Escherichia coli

Antimicrobial resistance presents a serious, worldwide threat to public health. New tools are required to combat the evolving problem. Here we report the systematic evolution of nucleic acid ligands to live Escherichia coli cells. Two SELEX methods were used to generate aptamers to the HB101: pAT153...

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Bibliographic Details
Main Author: Gowland, Robert Michael Nicholas
Other Authors: Gowers, Darren Matthew ; Scarlett, Garry ; Pickford, Andrew Robert
Published: University of Portsmouth 2015
Subjects:
572
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.690072