The effect of antiplatelet medications on innate immune activation

Objective - Clinical studies suggest that platelet P2Y12 inhibitors reduce mortality from sepsis, although the underlying mechanisms have not been clearly defined in vivo. We hypothesized that P2Y12 inhibitors may improve survival from sepsis by suppressing systemic inflammation and its prothromboti...

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Bibliographic Details
Main Author: Thomas, Mark
Other Authors: Storey, Robert F. ; Sabroe, Ian
Published: University of Sheffield 2015
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.686486