The role of the fetal microenvironment in abnormal fetal haematopoiesis in Down syndrome
Children with Down syndrome (DS; trisomy 21, T21) have a 500-fold risk of developing acute megakaryoblastic leukaemia (AMKL) in early childhood compared to children without DS. DS-AMKL is preceded by a transient neonatal leukaemia, unique to DS, caused by acquired mutations in the GATA1 gene in feta...
| Main Author: | |
|---|---|
| Other Authors: | |
| Published: |
Imperial College London
2014
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.679674 |