Prostaglandin E2 regulates neutrophil survival via EP2/PKA/NR4A2 signalling in the context of COPD

Chronic Obstructive Pulmonary Disease (COPD) is a neutrophil-associated pulmonary condition that is accompanied by chronic inflammation. Neutrophil lifespan is typically controlled by constitutive apoptosis, but their prolonged persistence at inflammatory sites is implicated in COPD pathology. Howev...

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Bibliographic Details
Main Author: Dannewitz, Svenja
Other Authors: Sabroe, Ian
Published: University of Sheffield 2015
Subjects:
610
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.677351