Mechanisms involved in the accumulation of mitochrondrial DNA defects following anti-HIV therapy

HIV-infected patients present with a range of pathologies that have been associated with mitochondrial toxicity, and more specifically, induced through exposure to the main class of antiretrovirals used in anti-HIV therapy (HAART), nucleoside analogue reverse transcriptase inhibitors, or NRTIs. It h...

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Bibliographic Details
Main Author: Gardner, Kristian
Published: University of Newcastle upon Tyne 2015
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674810