Gene targeting in mouse embryonal stem cells

This thesis is concerned with 'Hit and Run' gene targeting in ES cells, a method designed with the objective of introducing small mutations into the genome. The procedure relies on the integration of a vector carrying the desired mutation, and positive and negative selectable markers. Afte...

Full description

Bibliographic Details
Main Author: Pells, Stephen Christopher
Published: University of Edinburgh 1995
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.660507