Functional analysis of the DNA repair protein MBD4
The methylation of cytosine plays a fundamental role in mediating transcriptional repression. However, 5-methylcytosine can undergo spontaneous hydrolytic delamination to form thymine. It the resulting T:G mismatch is replicated prior to being repaired, a C:G to T:A transition mutation will be prese...
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University of Edinburgh
2006
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.654229 |