Generation and analysis of ES cells expressing individual isoforms of AML1/Runx1 gene in a constitutive and regulatable manner
AML1 long splice isoform regulates transcription of many haematopoietic specific genes and may act as both transcriptional activator and repressor. The AML1 short isoform which lacks the transactivation domain can bind DNA but is not capable of activating transcription; suggesting that it acts in a...
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University of Edinburgh
2005
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.653880 |