Investigation into the importance of DNA repair gene Ercc1 in the skin and central nervous system
Nucleotide excision repair (NER) is responsible for the removal of helix distorting lesions from DNA. In NER, ERCC1 acts in complex with XPF to make an incision 5’ of the lesion and as such is essential for this damage repair process. <i>Ercc1</i> null mice die at 3 weeks with severe liv...
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University of Edinburgh
2007
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.653723 |