Calmodulin activation of the reductase domain of mammalian neuronal nitric oxide synthase
In order to investigate the CaM activation mechanism of nNOS, the effect of the conformational changes of nNOSrd and the binding of NADP(H) on the redox potential of the flavins, cofactors were assessed for the isolated FAD and FMN sub-domains by OTTLE potentiometry. The results showed that the pres...
| Main Author: | |
|---|---|
| Published: |
University of Edinburgh
2006
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.651338 |