A transgenic analysis of the role of Smad4 in the mammary gland
To investigate the effects of Smad proteins in normal euploid cells, various Smads were over-expressed in embryonic stem cells (ES cells). Analysis of ligand-specific Smads 1, 2, 3 and the central mediator Smad4, showed that only Smad4 could induce both a G1 arrest and apoptosis. This confirmed a ro...
| Main Author: | |
|---|---|
| Published: |
University of Edinburgh
2001
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.649757 |