Structural analysis of the complex formed between the ansamycin antibiotic rifabutin and the BCL6 BTB-POZ domain
BCL6 is a zinc finger transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ~30-40% of the aggressive disease diffuse large B-cell lymphoma. BCL6 accomplishes its effects through the recruitment of co-repressors to the BTB-POZ domain of BCL6,...
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University of Leicester
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.643670 |