Investigation of the mutational consequences of defective mismatch repair in humans
One explanation why sequences are mutated frequently in MMR deficient colerectal cancer (CRC) is they are inherently prone to mutations. To investigate this hypothesis, MMR deficient cells (1b1-1260, 1b1-1261) derived from normal tissue (B-lymphocytes), have been utilised. A SP-PCR technique was emp...
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University of Edinburgh
2002
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.641185 |