Mechanism of IKK activation by the Kaposi's sarcoma-associated herpesvirus protein vFLIP and its cellular homologues
Activation of the NF-κB pathway is linked to cancer development and progression. Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV8) encodes vFLIP which binds to the NEMO/IKKγ subunit of IKK and constitutively activates NF-κB, leading to tumourigenesis. Cellular FLIPs, which share sequence homology...
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University College London (University of London)
2015
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639594 |