Exploring the role of the molecular chaperone Hsp104 in yeast [PSI+] prion propagation and transmission

[PSI+] is the prion form of the Sup35 protein in Saccharomyces cerevisiae. The molecular Hsp 104 chaperone is involved in the propagation of the [PSI+] by dissolving Sup35p prion fibres into the small seeds (propagons) needed to generate a new round propagation. Overexpression of the HSP104 gene res...

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Bibliographic Details
Main Author: Wongwigkarn, Jintana
Published: University of Kent 2013
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633824