Role of Rap and Rho GTPases in T-acute lymphoblastic leukaemia cell adhesion and migration

T-acute lymphoblastic leukaemia (T-ALL) is a common childhood cancer. Multiple genetic mutations have been identified in T-ALL patients. The most common is the mutation of the NOTCH 1 oncogene occurring in more than 50% of patients. Poor prognosis has often been shown to correlate with the migration...

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Bibliographic Details
Main Author: Infante, Elvira
Published: King's College London (University of London) 2013
Subjects:
611
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.628331