Mechanisms of monoubiquitination in the Fanconi anemia pathway
The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukaemia and bone marrow failure. The vital step of the pathway is the monoubiquitination of FANCD2 and FANCI by the RING E3 ligase...
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University College London (University of London)
2014
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626773 |