Insights into the Fanconi Anemia DNA repair pathway from the structure and interactions of human FANCL

The Fanconi Anemia (FA) pathway is critical for repair of DNA damage interstrand crosslinks (ICL). Mutations in the pathway lead to a rare genetic disorder known as FA, where patient’s symptoms include a high predisposition to cancers, anemia and developmental defects. The pathway is complex, consis...

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Bibliographic Details
Main Author: Hodson, C.
Published: University College London (University of London) 2014
Subjects:
570
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626732