Investigating the role of the actin cytoskeleton in hippo signalling
The Hippo pathway is composed of a phosphorylation cascade involving the kinases Hippo/MST and Warts/LATS, which inactivate the pro-growth transcriptional co-activator Yorkie/YAP. By sensing the status of the actin cytoskeleton, Yorkie/YAP is believed to respond to cell crowding and the rigidity of...
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University College London (University of London)
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.626085 |