Towards complete release from the E. coli periplasm for improved manufacturing
Escherichia coli is used to produce a wide variety of therapeutic proteins, such as Fab fragments. Many such proteins are expressed and retained within the periplasmic region of the cell, and after fermentation the proteins must be recovered for downstream processing using steps such as homogenisati...
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University College London (University of London)
2012
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625902 |