Cellular mechanisms in prion-mediated neurodegeneration

Prion diseases are fatal neurodegenerative disorders of both humans and other animals. The cause of prion-mediated neurodegeneration by conversion of the normal cellular prion protein (PrPC) to the disease-related isoform (PrPSc) remains unknown. Increasing evidence suggests a role for the ubiquitin...

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Bibliographic Details
Main Author: Deriziotis, P.
Published: University College London (University of London) 2009
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.625154