Molecular diversity and population structure at the CYP3A5 gene in Africa
The CYP450 superfamily of enzymes metabolise ~90% of all therapeutic drug. CYP3A5 is involved in the metabolism of multiple drugs and endogenous compounds. Enzyme expression is highly variable and associated with differential efficacy of therapeutic drugs and risk of adverse drug reactions (ADRs). F...
| Main Author: | |
|---|---|
| Published: |
University College London (University of London)
2012
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.617906 |