Novel DNA damage induced pathways to cancer : the role of PCAF histone acetyltransferase
Cell cycle checkpoints act as surveillance system and following DNA damage caused by ultraviolet (UV) or ionising irradiation (IR), ATM and ATR phosphorylate various downstream substrates that preserve the genome integrity. The tumor suppressor protein p53 is a target for ATM/ATR kinases and modulat...
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University of Manchester
2014
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603196 |