Recessive genetic screen for mismatch repair components in Blm-deficient ES cells

Phenotype-driven recessive genetic screens in diploid organisms require a strategy to render the mutation homozygous. Although homozygous mutant mice can be generated by breeding, a reliable method to make homozygous mutations in cultured cells has not been available, limiting recessive screens in c...

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Bibliographic Details
Main Author: Guo, G.
Published: University of Cambridge 2004
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599786