Total synthesis of dictyostatin and novel structural analogues as promising anticancer agents
The marine sponge-derived antimitotic polyketides discodermolide (12) and dictyostatin (16) are important natural product leads for the development of new anticancer agents. The first part of this thesis describes the design, synthesis and biological evaluation of a hybrid analogue 43 of discodermol...
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University of Cambridge
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599314 |